Abstract
Heparin, an anticoagulant, has been used in many forms to treat various diseases. These forms include soluble heparin and heparin immobilized to supporting matrices by physical adsorption, by covalent chemical methods and by photochemical attachment. These immobilization methods often require the use of spacers or linkers. This review examines and compares various techniques that have been used for the immobilization of heparin as well as applications of these immobilized heparins. In the applications reviewed, immobilized heparin is compared with soluble heparin for efficient and versatile use in each of the various applications.
Keywords: Heparin, Immobilization, Blood compatibility
Current Topics in Medicinal Chemistry
Title: Immobilization of Heparin: Approaches and Applications
Volume: 8 Issue: 2
Author(s): Robert J. Linhardt, Saravanababu Murugesan and Jin Xie
Affiliation:
Keywords: Heparin, Immobilization, Blood compatibility
Abstract: Heparin, an anticoagulant, has been used in many forms to treat various diseases. These forms include soluble heparin and heparin immobilized to supporting matrices by physical adsorption, by covalent chemical methods and by photochemical attachment. These immobilization methods often require the use of spacers or linkers. This review examines and compares various techniques that have been used for the immobilization of heparin as well as applications of these immobilized heparins. In the applications reviewed, immobilized heparin is compared with soluble heparin for efficient and versatile use in each of the various applications.
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Cite this article as:
Linhardt J. Robert, Murugesan Saravanababu and Xie Jin, Immobilization of Heparin: Approaches and Applications, Current Topics in Medicinal Chemistry 2008; 8 (2) . https://dx.doi.org/10.2174/156802608783378891
DOI https://dx.doi.org/10.2174/156802608783378891 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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