Abstract
Cystatins are thiol proteinase inhibitors ubiquitously present in mammalian body. In brain, they prevent unwanted proteolysis and are involved in several neurodegenerative diseases. In the present study, it has been demonstrated that photoactivated riboflavin and H2O2 induced modifications of high molecular mass goat brain cystatin (HM-GBC) leads to its inactivation and degradation. It was found that the damage with both the oxidants occurred mainly because of the hydroxyl radicals. It has been also proposed that susceptibility of HM-GBC to oxidation by reactive oxygen species generated in vivo arise from oxidative modifications may lead to damage of this significant protein as it is so well pronounced, in vitro.
Keywords: Mammalian cystatin, High molecular mass goat brain cystatin, riboflavin, H2O2, oxidative stress
Protein & Peptide Letters
Title: Oxidative Stress Induced Functional and Structural Modifications of High Molecular Mass Goat Brain Cystatin
Volume: 15 Issue: 1
Author(s): Bilqees Bano and Sadia Sumbul
Affiliation:
Keywords: Mammalian cystatin, High molecular mass goat brain cystatin, riboflavin, H2O2, oxidative stress
Abstract: Cystatins are thiol proteinase inhibitors ubiquitously present in mammalian body. In brain, they prevent unwanted proteolysis and are involved in several neurodegenerative diseases. In the present study, it has been demonstrated that photoactivated riboflavin and H2O2 induced modifications of high molecular mass goat brain cystatin (HM-GBC) leads to its inactivation and degradation. It was found that the damage with both the oxidants occurred mainly because of the hydroxyl radicals. It has been also proposed that susceptibility of HM-GBC to oxidation by reactive oxygen species generated in vivo arise from oxidative modifications may lead to damage of this significant protein as it is so well pronounced, in vitro.
Export Options
About this article
Cite this article as:
Bano Bilqees and Sumbul Sadia, Oxidative Stress Induced Functional and Structural Modifications of High Molecular Mass Goat Brain Cystatin, Protein & Peptide Letters 2008; 15 (1) . https://dx.doi.org/10.2174/092986608783330387
DOI https://dx.doi.org/10.2174/092986608783330387 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Characteristics of Self-Defining Memories in Middle-Aged and Older Adults
Current Aging Science Herbal Medication and Nutraceuticals for the Management of Anxiety and Depression
Current Psychopharmacology Towards the Management of Inflammation: Recent Developments of mPGES-1 Inhibitors
Recent Patents on CNS Drug Discovery (Discontinued) When “Chems” Meet Sex: A Rising Phenomenon Called “ChemSex”
Current Neuropharmacology Regulation of Innate Immune Responses in the Central Nervous System
CNS & Neurological Disorders - Drug Targets Blood-Brain-Barrier Models for the Investigation of Transporter- and Receptor-Mediated Amyloid-β Clearance in Alzheimers Disease
Current Alzheimer Research HMPAO-SPECT Can Discriminate between Patients with Subjective Cognitive Complaints with and without Cognitive Deficits and those with Mild Cognitive Impairment
Current Alzheimer Research Brain MRI, Apoliprotein E Genotype, and Plasma Homocysteine in American Indian Alzheimer Disease Patients and Indian Controls
Current Alzheimer Research Visible Light-Induced Photocatalytic Elimination of Organic Pollutants by TiO<sub>2</sub>: A Review
Current Organic Chemistry Stachydrine Inhibits PC12 Cell Apoptosis Induced by Aβ<sub>25-35</sub> in an in vitro Cell Model of Neurocognitive Disorders
Letters in Drug Design & Discovery Roles of Chemokine CXCL12 and its Receptors in Ischemic Stroke
Current Drug Targets Attempted Cell Cycle Induction in Post-Mitotic Neurons Occurs in Early and Late Apoptotic Programs Through Rb, E2F1, and Caspase 3
Current Neurovascular Research Adolescent Depression Screening: Not So Fast
Adolescent Psychiatry Smoking and Cognition
Current Drug Abuse Reviews Molecular and Clinical Aspects of the Target Therapy with the Calcimimetic Cinacalcet in the Treatment of Parathyroid Tumors
Current Cancer Drug Targets Disturbed Sleep Patterns in Elders with Mild Cognitive Impairment: The Role of Memory Decline and ApoE ε 4 Genotype
Current Alzheimer Research Rational Targeting of Peroxisome Proliferating Activated Receptor Subtypes
Current Medicinal Chemistry Chitosan-Gold Nanocomposite for Copper Ions Detection
Current Nanoscience Different Inductive Effects of Praziquantel Racemate and its Enantiomers on the Enzyme CYP3A4 Mediated by Pregnane X Receptor and its Variants
Current Drug Metabolism Caffeine; the Forgotten Potential for Parkinson's Disease
CNS & Neurological Disorders - Drug Targets