Abstract
The universal chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid (DOTA) and its bifunctional derivatives are widely used to label peptides with various metal ions for biomedical applications. Bifunctional DOTA derivatives and their conjugation to peptides has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals. This review covers the synthesis of DOTA-peptide conjugates, their potential use in biomedicine and the problems related to their applications.
Keywords: DOTA, peptides, conjugation, labeling, diagnostic, therapy
Mini-Reviews in Organic Chemistry
Title: Conjugation of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetracetic Acid (DOTA) and its Derivatives to Peptides: Synthesis, Applications and Future Prospects
Volume: 4 Issue: 4
Author(s): Z. Kovacs and L. M. De Leon-Rodriguez
Affiliation:
Keywords: DOTA, peptides, conjugation, labeling, diagnostic, therapy
Abstract: The universal chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid (DOTA) and its bifunctional derivatives are widely used to label peptides with various metal ions for biomedical applications. Bifunctional DOTA derivatives and their conjugation to peptides has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals. This review covers the synthesis of DOTA-peptide conjugates, their potential use in biomedicine and the problems related to their applications.
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Cite this article as:
Kovacs Z. and De Leon-Rodriguez M. L., Conjugation of 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetracetic Acid (DOTA) and its Derivatives to Peptides: Synthesis, Applications and Future Prospects, Mini-Reviews in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157019307782411671
DOI https://dx.doi.org/10.2174/157019307782411671 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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