Abstract
Angiotensin II, the primary active hormone in the Renin-Angiotensin System is a major vasoconstrictor implicated in the cause of hypertension. Research efforts have focused in the treatment of disease by blocking its release and more recently by competing its action on AT 1 receptors. This approach generated in the pharmaceutical market, losartan, and other derivatives. To better understand the stereoelectronic requirements that lead to the molecular basis of hypertension the stereochemical features of angiotensin II and its antagonists are studied.
Keywords: Antihypertensive Drugs, Renin-Angiotensin System, AT1 Antagonists, Angiotensin, RENIN ANGIOTENSIN SYSTEM, ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORS, RENIN INHIBITORS, Captopril, Enlapril, Remikiren
Mini-Reviews in Medicinal Chemistry
Title: Antihypertensive Drugs that Act on Renin-Angiotensin System with Emphasis in AT1 Antagonists
Volume: 1 Issue: 2
Author(s): T. Mavromoustakos, V. Apostolopoulos and J. Matsoukas
Affiliation:
Keywords: Antihypertensive Drugs, Renin-Angiotensin System, AT1 Antagonists, Angiotensin, RENIN ANGIOTENSIN SYSTEM, ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORS, RENIN INHIBITORS, Captopril, Enlapril, Remikiren
Abstract: Angiotensin II, the primary active hormone in the Renin-Angiotensin System is a major vasoconstrictor implicated in the cause of hypertension. Research efforts have focused in the treatment of disease by blocking its release and more recently by competing its action on AT 1 receptors. This approach generated in the pharmaceutical market, losartan, and other derivatives. To better understand the stereoelectronic requirements that lead to the molecular basis of hypertension the stereochemical features of angiotensin II and its antagonists are studied.
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Cite this article as:
Mavromoustakos T., Apostolopoulos V. and Matsoukas J., Antihypertensive Drugs that Act on Renin-Angiotensin System with Emphasis in AT1 Antagonists, Mini-Reviews in Medicinal Chemistry 2001; 1 (2) . https://dx.doi.org/10.2174/1389557013407115
DOI https://dx.doi.org/10.2174/1389557013407115 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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