The Therapeutic Potential for Catalytic Antibodies  From a Concept to a Promise

Lyn      H. Jones; Paul      Wentworth

Abstract

More than ten years have now elapsed since the first reports confirmed that antibodies not only label antigenic targets but can also perform catalytic functions. Much of the initial research in this area focussed on exploring the scope and utility of these biocatalysts both as enzyme mimics and as programmable protein catalysts. However, their potential in the biomedical field has also been probed. This review details the present perspective of catalytic antibodies as new tools for immunotherapy and specifically focuses on their application to prodrug activation and drug inactivation.

Keywords: Catalytic Antibodies, PRODRUG ACTIVATION, Eschericia coli, Topoisomerase inhibitors doxorubicin, camptothecin, Diels-Alder reaction, DRUG INACTIVATION, Superoxide dismutase, Transition state analog

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Mini-Reviews in Medicinal Chemistry

Title: The Therapeutic Potential for Catalytic Antibodies From a Concept to a Promise

Volume: 1 Issue: 2

Author(s): Lyn H. Jones and Paul Wentworth

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Abstract: More than ten years have now elapsed since the first reports confirmed that antibodies not only label antigenic targets but can also perform catalytic functions. Much of the initial research in this area focussed on exploring the scope and utility of these biocatalysts both as enzyme mimics and as programmable protein catalysts. However, their potential in the biomedical field has also been probed. This review details the present perspective of catalytic antibodies as new tools for immunotherapy and specifically focuses on their application to prodrug activation and drug inactivation.

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Cite this article as:

H. Jones Lyn and Wentworth Paul, The Therapeutic Potential for Catalytic Antibodies From a Concept to a Promise, Mini-Reviews in Medicinal Chemistry 2001; 1 (2) . https://dx.doi.org/10.2174/1389557013407070

DOI https://dx.doi.org/10.2174/1389557013407070	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607

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