Abstract
Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.
Keywords: acat inhibitors, molecular modeling, glycyrrhizin, glycyrrhiza glabra
Mini-Reviews in Medicinal Chemistry
Title: Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method
Volume: 2 Issue: 2
Author(s): M. Ablise, A. Cartier, G. Siest, S. Visvikis and V. Loppinet
Affiliation:
Keywords: acat inhibitors, molecular modeling, glycyrrhizin, glycyrrhiza glabra
Abstract: Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.
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Cite this article as:
Ablise M., Cartier A., Siest G., Visvikis S. and Loppinet V., Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method, Mini-Reviews in Medicinal Chemistry 2002; 2 (2) . https://dx.doi.org/10.2174/1389557024605528
DOI https://dx.doi.org/10.2174/1389557024605528 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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