Crystallization and Preliminary X-Ray Crystallographic Studies of Trichosanthin Delta C7

Title: Crystallization and Preliminary X-Ray Crystallographic Studies of Trichosanthin Delta C7

Volume: 9 Issue: 3

Author(s): X. Li, Y. Ding, H. Too, Z. Wang, Yi. Liu, Y. Dong, P. Shaw and Z. Rao

Affiliation:

Keywords: trichosan thin deltac7, rip, ribosome-inactivating protein, trichosanthin(tcs), tcs-c7

Abstract: Trichosanthin (TCS) is a type I ribosome-inactivating protein (RIP) which possesses rRNA N-glycosidase activity. TCS has various pharmacological properties. It is possible to reduce the antigenicity of TCS by deleting up to seven C-terminal residues of TCS (TCS-C7) with minimal effect on its activity [1]. TCS-C7 has been crystallized and the crystal diffracted to 1.8 Å. It belongs to space group P21, with unit-cell parameters a=71.6Å, b=74.4Å, c=87.6Å, β=97.0°. It is given that there are four molecules per asymmetric unit.

Cite this article as:

Li X., Ding Y., Too H., Wang Z., Liu Yi., Dong Y., Shaw P. and Rao Z., Crystallization and Preliminary X-Ray Crystallographic Studies of Trichosanthin Delta C7, Protein & Peptide Letters 2002; 9 (3) . https://dx.doi.org/10.2174/0929866023408742