Abstract
NO is produced endogenously from L-arginine by NOSs. Among its multiple activities, the homeostatic control of the vascular endothelium is crucial for atherosclerosis, a pathogenic condition connected with elevated levels of LDL, the main plasma cholesterol carrier. Oxidised LDL is proatheromatic, and toxic peroxidation products contribute to further endothelial damage. .NO controls vascular tone, inhibits LDL oxidation and has hypocholesterolaemic activity. This review is referred to the chemistry, biology and role of .NO on atherosclerosis and its treatment by .NO donors or modulators.
Keywords: atherosclerosis, l-arginine, multiple activities, plasma cholesterol carrier, modulators, iron-containing enzymes, high diffusion capacity, high density lipoprotein(hdl)
Mini-Reviews in Medicinal Chemistry
Title: Nitric Oxide in Atherosclerosis
Volume: 2 Issue: 6
Author(s): E. A. Rekka and M. C. Chrysselis
Affiliation:
Keywords: atherosclerosis, l-arginine, multiple activities, plasma cholesterol carrier, modulators, iron-containing enzymes, high diffusion capacity, high density lipoprotein(hdl)
Abstract: NO is produced endogenously from L-arginine by NOSs. Among its multiple activities, the homeostatic control of the vascular endothelium is crucial for atherosclerosis, a pathogenic condition connected with elevated levels of LDL, the main plasma cholesterol carrier. Oxidised LDL is proatheromatic, and toxic peroxidation products contribute to further endothelial damage. .NO controls vascular tone, inhibits LDL oxidation and has hypocholesterolaemic activity. This review is referred to the chemistry, biology and role of .NO on atherosclerosis and its treatment by .NO donors or modulators.
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Cite this article as:
Rekka A. E. and Chrysselis C. M., Nitric Oxide in Atherosclerosis, Mini-Reviews in Medicinal Chemistry 2002; 2 (6) . https://dx.doi.org/10.2174/1389557023405666
DOI https://dx.doi.org/10.2174/1389557023405666 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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