Abstract
Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways.
Keywords: chemotherapeutic target, protozoan parasites, polyamine analogs, ornithine decarboxylase, backconversion pathway, african trypanosomes, nucleoside transporters, dfmo
Mini-Reviews in Medicinal Chemistry
Title: Polyamine Metabolism as Chemotherapeutic Target in Protozoan Parasites
Volume: 2 Issue: 6
Author(s): C. J. Bacchi and N. Yarlett
Affiliation:
Keywords: chemotherapeutic target, protozoan parasites, polyamine analogs, ornithine decarboxylase, backconversion pathway, african trypanosomes, nucleoside transporters, dfmo
Abstract: Polyamines are essential cell constituents for all organisms. The present review highlights important differences in the synthesis, degradation, and interconversion of polyamines between the protozoan parasites (Trypanosoma brucei, Trypanosoma cruzi, Cryptosporidium parvum and Trichomonas vaginalis) and their mammalian hosts. Approaches include development of mono- and di-substituted polyamine analogs targeting polyamine interconversion, as well as more traditional targeting of synthetic enzymes and related pathways.
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Cite this article as:
Bacchi J. C. and Yarlett N., Polyamine Metabolism as Chemotherapeutic Target in Protozoan Parasites, Mini-Reviews in Medicinal Chemistry 2002; 2 (6) . https://dx.doi.org/10.2174/1389557023405549
DOI https://dx.doi.org/10.2174/1389557023405549 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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