Abstract
An apparent discrepancy in the data for the Gibbs free energy change as a function of temperature at different pHs, originally published by Brandts in 1965 and repeated by Brandts and Hunt in 1967 with an unexplained change in sign, has lead to close to 40 years of misguided thinking in examining the thermodynamics of protein unfolding, including the frequently promulgated idea of cold denaturation. We have carried out a detailed analysis based on the Planck-Benzinger approach, which is very powerful in clarifying the fundamental aspects of biochemical energetics.
Keywords: Misconceptions, Thermodynamic, Gibbs Free Energy, Ribonuclease A
Protein & Peptide Letters
Title: Misconceptions arising from a Sign Discrepancy in Thermodynamic Data for the Gibbs Free Energy Profile of Ribonuclease A
Volume: 9 Issue: 4
Author(s): Paul W. Chun
Affiliation:
Keywords: Misconceptions, Thermodynamic, Gibbs Free Energy, Ribonuclease A
Abstract: An apparent discrepancy in the data for the Gibbs free energy change as a function of temperature at different pHs, originally published by Brandts in 1965 and repeated by Brandts and Hunt in 1967 with an unexplained change in sign, has lead to close to 40 years of misguided thinking in examining the thermodynamics of protein unfolding, including the frequently promulgated idea of cold denaturation. We have carried out a detailed analysis based on the Planck-Benzinger approach, which is very powerful in clarifying the fundamental aspects of biochemical energetics.
Export Options
About this article
Cite this article as:
Chun W. Paul, Misconceptions arising from a Sign Discrepancy in Thermodynamic Data for the Gibbs Free Energy Profile of Ribonuclease A, Protein & Peptide Letters 2002; 9 (4) . https://dx.doi.org/10.2174/0929866023408625
DOI https://dx.doi.org/10.2174/0929866023408625 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers