Abstract
In order to gain a therapeutic response after mucosal administration peptide drugs have to permeate the absorption membrane based on the mucus layer (I) and the epithelial tissue (II ) in significant quantities. The peptide drug transport across the membrane can be improved by the use of mucolytic agents and the permeation enhancers. The generation of novel, more potent permeation enhancers, based on an improved knowledge of the absorption membrane in combination with the appropriate delivery systems will strongly improve the bioavailability of mucosally applied peptide drugs.
Keywords: mucosal membrane, peptide drug delivery, absorption barrier, permeation enhancer, mucolytic agent
Mini-Reviews in Medicinal Chemistry
Title: Biomembrane Permeability of Peptides: Strategies to Improve Their Mucosal Uptake
Volume: 2 Issue: 4
Author(s): Andreas Bernkop-Schnurch and Andreas E. Clausen
Affiliation:
Keywords: mucosal membrane, peptide drug delivery, absorption barrier, permeation enhancer, mucolytic agent
Abstract: In order to gain a therapeutic response after mucosal administration peptide drugs have to permeate the absorption membrane based on the mucus layer (I) and the epithelial tissue (II ) in significant quantities. The peptide drug transport across the membrane can be improved by the use of mucolytic agents and the permeation enhancers. The generation of novel, more potent permeation enhancers, based on an improved knowledge of the absorption membrane in combination with the appropriate delivery systems will strongly improve the bioavailability of mucosally applied peptide drugs.
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Cite this article as:
Bernkop-Schnurch Andreas and Clausen E. Andreas, Biomembrane Permeability of Peptides: Strategies to Improve Their Mucosal Uptake, Mini-Reviews in Medicinal Chemistry 2002; 2 (4) . https://dx.doi.org/10.2174/1389557023406007
DOI https://dx.doi.org/10.2174/1389557023406007 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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