Abstract
tRNA is the adaptor in the translation process. The ribosome has three sites for tRNA, the A-, P-, and E-sites. The tRNAs bridge between the ribosomal subunits with the decoding site and the mRNA on the small or 30S subunit and the peptidyl transfer site on the large or 50S subunit. The possibility that translation release factors could mimic tRNA has been discussed for a long time, since their function is very similar to that of tRNA. They identify stop codons of the mRNA presented in the decoding site and hydrolyse the nascent peptide from the peptidyl tRNA in the peptidyl transfer site. The structures of eubacterial release factors are not yet known, and the first example of tRNA mimicry was discovered when elongation factor G (EF-G) was found to have a closely similar shape to a complex of elongation factor Tu (EF-Tu) with aminoacyl-tRNA. An even closer imitation of the tRNA shape is seen in ribosome recycling factor (RRF). The number of proteins mimicking tRNA is rapidly increasing. This primari ly concerns translation factors. It is now evident that in some sense they are either tRNA mimics, GTPases or possibly both.
Keywords: tRNA Binding, elongation factor g ef-g, elongation factor tu ef-tu, gtpases, eubacterial translation factors, initiation, elongation, termination, recycling, eucaryotic initiation factors 5a and b, ribosome release factor
Current Protein & Peptide Science
Title: Is tRNA Binding or tRNA Mimicry Mandatory for Translation Factors?
Volume: 3 Issue: 1
Author(s): Ole Kristensen, Martin Laurberg, Anders Liljas and Maria Selmer
Affiliation:
Keywords: tRNA Binding, elongation factor g ef-g, elongation factor tu ef-tu, gtpases, eubacterial translation factors, initiation, elongation, termination, recycling, eucaryotic initiation factors 5a and b, ribosome release factor
Abstract: tRNA is the adaptor in the translation process. The ribosome has three sites for tRNA, the A-, P-, and E-sites. The tRNAs bridge between the ribosomal subunits with the decoding site and the mRNA on the small or 30S subunit and the peptidyl transfer site on the large or 50S subunit. The possibility that translation release factors could mimic tRNA has been discussed for a long time, since their function is very similar to that of tRNA. They identify stop codons of the mRNA presented in the decoding site and hydrolyse the nascent peptide from the peptidyl tRNA in the peptidyl transfer site. The structures of eubacterial release factors are not yet known, and the first example of tRNA mimicry was discovered when elongation factor G (EF-G) was found to have a closely similar shape to a complex of elongation factor Tu (EF-Tu) with aminoacyl-tRNA. An even closer imitation of the tRNA shape is seen in ribosome recycling factor (RRF). The number of proteins mimicking tRNA is rapidly increasing. This primari ly concerns translation factors. It is now evident that in some sense they are either tRNA mimics, GTPases or possibly both.
Export Options
About this article
Cite this article as:
Kristensen Ole, Laurberg Martin, Liljas Anders and Selmer Maria, Is tRNA Binding or tRNA Mimicry Mandatory for Translation Factors?, Current Protein & Peptide Science 2002; 3 (1) . https://dx.doi.org/10.2174/1389203023380837
DOI https://dx.doi.org/10.2174/1389203023380837 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pulmonary Manifestations of Rheumatoid Arthritis, Psoriatic Arthritis and Peripheral Spondyloarthritis: Prevalence, Diagnostic Approach and Treatment Options
Current Rheumatology Reviews Adherence to Anti-Retroviral Therapy in North Central Nigeria
Current HIV Research Fish and Apoptosis: Studies in Disease and Pharmaceutical Design
Current Pharmaceutical Design Angiotensin-Converting Enzyme 2 Roles in the Pathogenesis of COVID-19
Current Hypertension Reviews Anti-Inflammatory Effects of Antidepressants: Possibilities for Preventives Against Alzheimers Disease
Central Nervous System Agents in Medicinal Chemistry EDITORIAL: Vaccinology in the 21st century
Current Topics in Medicinal Chemistry Dihydrofolate Reductase as a Model for Enzyme Catalysis
Current Biotechnology Association of Genetic Variation with Pneumonia
Current Respiratory Medicine Reviews Non-Clinical Investigation of Tuberculosis Drugs: Conjugated Norbornene- Based Nanocarriers Toxic Impacts on Zebrafish
Current Nanomedicine Use of Etanercept in the Treatment of Psoriasis and Psoriatic Arthritis
Reviews on Recent Clinical Trials Is Renalase a Novel Player in Catecholaminergic Signaling? The Mystery of the Catalytic Activity of an Intriguing New Flavoenzyme
Current Pharmaceutical Design Editorial
Current Molecular Medicine New Progress in Azole Compounds as Antimicrobial Agents
Mini-Reviews in Medicinal Chemistry Design of Novel Phosphopantetheine Adenylyltransferase Inhibitors: A Potential New Approach to Tackle <i>Mycobacterium tuberculosis</i>
Current Topics in Medicinal Chemistry Tailored Multi-Target Agents. Applications and Design Considerations
Current Pharmaceutical Design Epoxide Hydrolases and their Application in Organic Synthesis
Current Organic Chemistry Present and Future Treatment of Mycobacteria
Anti-Infective Agents in Medicinal Chemistry Biotechnological Approaches to the Production of Idiotypic Vaccines and Antiidiotypic Antibiotics
Current Pharmaceutical Biotechnology Curcumin: Structure-Activity Relationship Towards its Role as a Versatile Multi-Targeted Therapeutics
Mini-Reviews in Organic Chemistry New Prospects for Nelfinavir in Non-HIV-Related Diseases
Current Molecular Pharmacology