A Synthetic Strategy for on-Resin Amino Acid Specific Multiple Fatty Acid Acylation of Peptides

Title: A Synthetic Strategy for on-Resin Amino Acid Specific Multiple Fatty Acid Acylation of Peptides

Volume: 9 Issue: 5

Author(s): Avaronnan Harishchandran, Bhattaram Pallavi and Ramakrishnan Nagaraj

Affiliation:

Keywords: acylation, myristic acid, palmitic acid, multiple acylation, peptide synthesis

Abstract: Covalent modification with fatty acids is observed in several proteins that play crucial roles in cellular physiology. In this paper, a convenient method for the generation of multiple fatty acylated synthetic peptides is described. Peptides were synthesized using solid phase procedures with fluorenylmethoxycarbonyl α-amino protected amino acids. Acetamidomethyl protected cysteines were employed. The thiol protecting group was selectively deprotected and acylation was carried out on the resin-bound peptides. The strategy described in this report is applicable to any peptide sequence.

Cite this article as:

Harishchandran Avaronnan, Pallavi Bhattaram and Nagaraj Ramakrishnan, A Synthetic Strategy for on-Resin Amino Acid Specific Multiple Fatty Acid Acylation of Peptides, Protein & Peptide Letters 2002; 9 (5) . https://dx.doi.org/10.2174/0929866023408571