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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Analysis of Fibril Formation of Amyloid-β- Protein by Stretched Exponential Function

Author(s): Ken-ichi Shinozaki, Takeo Konakahara, Hiroaki Okuno and Masato Kodaka

Volume 10, Issue 6, 2003

Page: [569 - 574] Pages: 6

DOI: 10.2174/0929866033478582

Price: $65

Abstract

Kinetic behavior of aggregation of amyloid-β-protein (Aβ) is represented by a stretched exponential function, F=A{1-exp(-Btn)}. Differences in temperature-dependence of A, B and n are studied for Aβ 1-40 and Aβ 1-42. As the temperature is lowered, parameter A is increased, parameter B is decreased and parameter n is increased in Aβ 1-40, while these parameters are less sensitive to temperature in a more hydrophobic protein Aβ 1-42. ln B is a linear function of n, which is shown by ln B = -6.34n + 3.69.

Keywords: fibril formation, amyloid-b-protein, stretched exponential function, hydrophobic protein


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