Abstract
Porphyromonas gingivalis is a black-pigmented anaerobic gram-negative bacterium that is a major pathogen of chronic adult periodontitis, an inflammatory disease of toothsupporting tissues. P. gingivalis possesses a number of potential virulence factors. Among them, cell-surface-associated and secreted proteinases such as Arg-gingipain and Lys-gingipain have received much attention because they can degrade various host proteins and cause inflammation. Molecular genetic analysis is extremely powerful to evaluate the significance of each virulence factor in a pathogenic microorganism. This review will describe the introduction of molecular genetics to analysis of pathogenesis of P. gingivalis and the findings that have been obtained using knockout mutants of various potential virulence factors, especially proteinases.
Keywords: molecular genetics, porphyromonas gingivalis, gingipains, virulence factors, chronic adult periodontitis, toothsupporting tissues, arg-gingipain, lys-gingipain, proteinases
Current Protein & Peptide Science
Title: Molecular Genetics of Porphyromonas gingivalis: Gingipains and other Virulence Factors
Volume: 4 Issue: 6
Author(s): K. Nakayama
Affiliation:
Keywords: molecular genetics, porphyromonas gingivalis, gingipains, virulence factors, chronic adult periodontitis, toothsupporting tissues, arg-gingipain, lys-gingipain, proteinases
Abstract: Porphyromonas gingivalis is a black-pigmented anaerobic gram-negative bacterium that is a major pathogen of chronic adult periodontitis, an inflammatory disease of toothsupporting tissues. P. gingivalis possesses a number of potential virulence factors. Among them, cell-surface-associated and secreted proteinases such as Arg-gingipain and Lys-gingipain have received much attention because they can degrade various host proteins and cause inflammation. Molecular genetic analysis is extremely powerful to evaluate the significance of each virulence factor in a pathogenic microorganism. This review will describe the introduction of molecular genetics to analysis of pathogenesis of P. gingivalis and the findings that have been obtained using knockout mutants of various potential virulence factors, especially proteinases.
Export Options
About this article
Cite this article as:
Nakayama K., Molecular Genetics of Porphyromonas gingivalis: Gingipains and other Virulence Factors, Current Protein & Peptide Science 2003; 4 (6) . https://dx.doi.org/10.2174/1389203033486983
DOI https://dx.doi.org/10.2174/1389203033486983 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mechanisms of Thrombosis, Available Treatments and Management Challenges Presented by Thromboangiitis Obliterans
Current Medicinal Chemistry Serum Zinc and β D Glucuronidase Enzyme Level in Type 2 Diabetes Mellitus with Periodontitis
Current Diabetes Reviews Epigenetic Regulation of Osteogenic Differentiation of Mesenchymal Stem Cells
Current Stem Cell Research & Therapy Peironimev-Plus® in the Treatment of Chronic Inflammation of Tunica Albuginea (Peyronie’s Disease). Results of a Controlled Study
Inflammation & Allergy - Drug Targets (Discontinued) Strategy for the Treatment of Helicobacter pylori Infection
Current Pharmaceutical Design Recent Developments in Collagen Patents
Recent Patents on Regenerative Medicine From Multiple PAR1 Receptor/Protein Interactions to their Multiple Therapeutic Implications
Current Topics in Medicinal Chemistry Potential Replication of Induced Pluripotent Stem Cells for Craniofacial Reconstruction
Current Stem Cell Research & Therapy Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
Letters in Drug Design & Discovery Biomaterials for Gene Delivery Atelocollagen-mediated Controlled Release of Molecular Medicines
Current Gene Therapy Nucleotide Second Messenger Signaling as a Target for the Control of Bacterial Biofilm Formation
Current Topics in Medicinal Chemistry Low Complexity Adaptive Nonlinear Models for the Diagnosis of Periodontal Disease
International Journal of Sensors, Wireless Communications and Control Diabetes and Periodontal Diseases: Interplay and Links
Current Diabetes Reviews Oral Pathogens, Immunity, and Periodontal Diseases
Current Immunology Reviews (Discontinued) The Effects of Mesenchymal Stem Cells in Craniofacial Tissue Engineering
Current Stem Cell Research & Therapy The Inflammation Paradigm and Coronary Artery Disease: What Celsus, Virchow and Gene Knock Outs Have Taught Us
Cardiovascular & Hematological Disorders-Drug Targets Battle for Pluripotency: Derivation of Induced Pluripotent Stem Cells
Recent Patents on Regenerative Medicine Biomimetic Oxidations of Xenobiotics by Metalloporphyrin and Salen Catalysts: Recent Applications
Current Catalysis Antioxidant Response of Osteoblasts to Doxycycline in an Inflammatory Model Induced by C-reactive Protein and Interleukin-6
Infectious Disorders - Drug Targets New Biological Insights in the Immunomodulatory Effects of Mucosal Polybacterial Vaccines in Clinical Practice
Current Pharmaceutical Design