Abstract
The search for new NK2 receptor antagonists have resulted in the discovery of several different classes of compounds with promise to have clinical utility. Clearly, the first reported non-peptide NK2 receptor antagonist (SR- 48,968) has inspired a lot of effort in the area, but over the years other approaches have also been fruitful. These include optimisation of hits from random screening and modifying compounds with NK3 receptor antagonistic properties into selective NK2 receptor antagonists. This is also an area where cyclic peptides and derivatives have been extensively examined. So far, no NK2 receptor antagonist has reached the market, but several clinical trials are in progress.
Keywords: nk2 receptor antagonists, nk2 receptor, sr- 48,968), decapeptide, neurokinin a
Current Topics in Medicinal Chemistry
Title: Recent Developments in the Medicinal Chemistry of NK2 Receptor Antagonists
Volume: 3 Issue: 12
Author(s): Anders Johansson
Affiliation:
Keywords: nk2 receptor antagonists, nk2 receptor, sr- 48,968), decapeptide, neurokinin a
Abstract: The search for new NK2 receptor antagonists have resulted in the discovery of several different classes of compounds with promise to have clinical utility. Clearly, the first reported non-peptide NK2 receptor antagonist (SR- 48,968) has inspired a lot of effort in the area, but over the years other approaches have also been fruitful. These include optimisation of hits from random screening and modifying compounds with NK3 receptor antagonistic properties into selective NK2 receptor antagonists. This is also an area where cyclic peptides and derivatives have been extensively examined. So far, no NK2 receptor antagonist has reached the market, but several clinical trials are in progress.
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Cite this article as:
Johansson Anders, Recent Developments in the Medicinal Chemistry of NK2 Receptor Antagonists, Current Topics in Medicinal Chemistry 2003; 3 (12) . https://dx.doi.org/10.2174/1568026033451835
DOI https://dx.doi.org/10.2174/1568026033451835 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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