Inhibitory And Promotive Effects Of Polyamines On Transglutaminase-Induced Protein Polymerization

Naoko      Sato; Yosuke      Ohtake; Hiroyuki      Kohno; Shinya      Abe; Yasuhito      Ohkubo

Abstract

Transglutaminase (TGase) has been reported to be involved in the regulation of cell growth. We examined the effects of polyamines on TGase activity. The polymerization of casein was inhibited by putrescine (PUT) and spermidine (SPD). On the other hand, polymerization of N,N-dimethylcasein was increased by spermine (SPM) and SPD. These results suggested polyamines played two distinct roles as inhibitor and promoter for TGase-catalyzed protein polymerization.

Keywords: transglutaminase, polyamine, putrescine, spermidine, spermine

« Previous Next »

Rights & Permissions Print Cite

Protein & Peptide Letters

Title: Inhibitory And Promotive Effects Of Polyamines On Transglutaminase-Induced Protein Polymerization

Volume: 10 Issue: 4

Author(s): Naoko Sato, Yosuke Ohtake, Hiroyuki Kohno, Shinya Abe and Yasuhito Ohkubo

Affiliation:

Keywords: transglutaminase, polyamine, putrescine, spermidine, spermine

Abstract: Transglutaminase (TGase) has been reported to be involved in the regulation of cell growth. We examined the effects of polyamines on TGase activity. The polymerization of casein was inhibited by putrescine (PUT) and spermidine (SPD). On the other hand, polymerization of N,N-dimethylcasein was increased by spermine (SPM) and SPD. These results suggested polyamines played two distinct roles as inhibitor and promoter for TGase-catalyzed protein polymerization.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Sato Naoko, Ohtake Yosuke, Kohno Hiroyuki, Abe Shinya and Ohkubo Yasuhito, Inhibitory And Promotive Effects Of Polyamines On Transglutaminase-Induced Protein Polymerization, Protein & Peptide Letters 2003; 10 (4) . https://dx.doi.org/10.2174/0929866033478816