Abstract
Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-Cnucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. Examples are given to exemplify the promise these compounds hold for the treatments of biological disorders.
Keywords: imino-sugar-based, iminonucleosides, imino-c-nucleosides
Current Topics in Medicinal Chemistry
Title: Imino-Sugar-Based Nucleosides
Volume: 3 Issue: 5
Author(s): Vern L. Schramm and Peter C. Tyler
Affiliation:
Keywords: imino-sugar-based, iminonucleosides, imino-c-nucleosides
Abstract: Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-Cnucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. Examples are given to exemplify the promise these compounds hold for the treatments of biological disorders.
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Cite this article as:
Schramm L. Vern and Tyler C. Peter, Imino-Sugar-Based Nucleosides, Current Topics in Medicinal Chemistry 2003; 3 (5) . https://dx.doi.org/10.2174/1568026033452465
DOI https://dx.doi.org/10.2174/1568026033452465 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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