Abstract
A hydroxamic acid moiety has been demonstrated as the key structural element in many highly potent and selective inhibitors against a variety of metalloprotease enzymes, such as MMPs, TACE, HDAC, PDF, etc. Over the last several years, there has been a rapid growth of literature and patent applications dealing with the development of the hydroxamic acid-based inhibitors. This review highlights the most recent examples to show their potential therapeutic applications.
Keywords: hydroxamic acids, mmps, tace, hdac, hydroxamic acid-based inhibitors
Mini-Reviews in Medicinal Chemistry
Title: Molecular Diversity of Hydroxamic Acids: Part II. Potential Therapeutic Applications
Volume: 3 Issue: 6
Author(s): Boliang Lou and Kexin Yang
Affiliation:
Keywords: hydroxamic acids, mmps, tace, hdac, hydroxamic acid-based inhibitors
Abstract: A hydroxamic acid moiety has been demonstrated as the key structural element in many highly potent and selective inhibitors against a variety of metalloprotease enzymes, such as MMPs, TACE, HDAC, PDF, etc. Over the last several years, there has been a rapid growth of literature and patent applications dealing with the development of the hydroxamic acid-based inhibitors. This review highlights the most recent examples to show their potential therapeutic applications.
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Cite this article as:
Lou Boliang and Yang Kexin, Molecular Diversity of Hydroxamic Acids: Part II. Potential Therapeutic Applications, Mini-Reviews in Medicinal Chemistry 2003; 3 (6) . https://dx.doi.org/10.2174/1389557033487872
DOI https://dx.doi.org/10.2174/1389557033487872 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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