Abstract
A “snapshot” of current medicinal chemistry work on bioavailability is drawn from issues of J. Med. Chem. covering the time period between September 2001 and September 2002. An exhaustive compilation of reported absolute oral bioavailability (F) values for this period is included, covering 34 structural series and 107 distinct compounds, with data for multiple species in many cases. This is supplemented with a discussion of more qualitative oral bioavailability results, and with illustrative examples addressing clearance, prodrug design, and blood / brain barrier penetration problems. Papers discussing predictions pertaining to one or another aspect of bioavailability are also discussed, and some thoughts on future directions of work on in silico prediction in this area are presented.
Keywords: molecular design, bioavailability
Current Topics in Medicinal Chemistry
Title: Molecular Design and Bioavailability
Volume: 3 Issue: 11
Author(s): Robert D. Clark and Philippa R.N. Wolohan
Affiliation:
Keywords: molecular design, bioavailability
Abstract: A “snapshot” of current medicinal chemistry work on bioavailability is drawn from issues of J. Med. Chem. covering the time period between September 2001 and September 2002. An exhaustive compilation of reported absolute oral bioavailability (F) values for this period is included, covering 34 structural series and 107 distinct compounds, with data for multiple species in many cases. This is supplemented with a discussion of more qualitative oral bioavailability results, and with illustrative examples addressing clearance, prodrug design, and blood / brain barrier penetration problems. Papers discussing predictions pertaining to one or another aspect of bioavailability are also discussed, and some thoughts on future directions of work on in silico prediction in this area are presented.
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Cite this article as:
Clark D. Robert and Wolohan R.N. Philippa, Molecular Design and Bioavailability, Current Topics in Medicinal Chemistry 2003; 3 (11) . https://dx.doi.org/10.2174/1568026033451952
DOI https://dx.doi.org/10.2174/1568026033451952 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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