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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Catalytic, Asymmetric Synthesis of Cyanohydrin Esters: The Effect of Anhydride Structure on Enantioselectivity

Author(s): Y. N. Belokon, P. Carta and M. North

Volume 1, Issue 1, 2004

Page: [81 - 83] Pages: 3

DOI: 10.2174/1570178043488617

Abstract

A bimetallic titanium(salen) complex has been shown to catalyse the asymmetric addition of potassium cyanide to aldehydes in the presence of a range of anhydrides, leading to cyanohydrin esters. Linear aliphatic anhydrides (acetic and propionic) gave products with higher enantiomeric purity than those obtained using pivalic or benzoic anhydrides.

Keywords: cyanohydrin, catalyst, ester, titanium, salen


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