A General Access to 2-Silylthiazolidines and Their Reactions Under Fluoride Ion Conditions

Title: A General Access to 2-Silylthiazolidines and Their Reactions Under Fluoride Ion Conditions

Volume: 1 Issue: 1

Author(s): Antonella Capperucci, Alessandro Degl'Innocenti, Tiziano Nocentini, Alessandro Mordini, Simona Biondi and Francesca Dini

Affiliation:

Keywords: Silylthiazolidines, bromomethoxymethyl, thiazolidines

Abstract: 2-Trimethylsilylthiazolidines were readily obtained through reaction of aminoethanethiol with (bromomethoxymethyl)trimethylsilane and efficiently N-functionalized with a variety of protecting groups. Such N-protected thiazolidines can then be satisfactorily reacted with several organic electrophiles under fluoride ion conditions, with a clean transfer of the thiazolidine moiety, to afford good yields of 2- functionalized heterocycles.

Cite this article as:

Capperucci Antonella, Degl'Innocenti Alessandro, Nocentini Tiziano, Mordini Alessandro, Biondi Simona and Dini Francesca, A General Access to 2-Silylthiazolidines and Their Reactions Under Fluoride Ion Conditions, Letters in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570178043488815