Abstract
Combinatorial chemistry has had a major impact on the discovery and optimisation of potential lead compounds. This review details some of the fundamental principles behind combinatorial chemistry and describes a variety of methods employed in the search for new therapeutically interesting compounds including the concept of dynamic combinatorial chemistry as a method of selecting active compounds from a mixture. It also outlines methods used to analyse resin bound products and describes how solution phase library generation may be aided by the use of resin bound reagents and scavengers.
Keywords: Methodologies, scavengers, combinatorial chemistry
Current Topics in Medicinal Chemistry
Title: The Impact of Combinatorial Methodologies on Medicinal Chemistry
Volume: 4 Issue: 7
Author(s): Rosario M. Sanchez-Martin, Stifun Mittoo and Mark Bradley
Affiliation:
Keywords: Methodologies, scavengers, combinatorial chemistry
Abstract: Combinatorial chemistry has had a major impact on the discovery and optimisation of potential lead compounds. This review details some of the fundamental principles behind combinatorial chemistry and describes a variety of methods employed in the search for new therapeutically interesting compounds including the concept of dynamic combinatorial chemistry as a method of selecting active compounds from a mixture. It also outlines methods used to analyse resin bound products and describes how solution phase library generation may be aided by the use of resin bound reagents and scavengers.
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Cite this article as:
Sanchez-Martin M. Rosario, Mittoo Stifun and Bradley Mark, The Impact of Combinatorial Methodologies on Medicinal Chemistry, Current Topics in Medicinal Chemistry 2004; 4 (7) . https://dx.doi.org/10.2174/1568026043451113
DOI https://dx.doi.org/10.2174/1568026043451113 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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