Abstract
The sympathetic nervous system (SNS) has a major role in homeostatic control of inflammatory and antigen specific immune reactions. This review summarizes the evidence that the SNS can enhance or suppress immune function, that SNS dysregulation is a critical component of the immune system dysregulation that underlies rheumatoid arthritis (RA) pathology and that the SNS may be targeted in RA to restore immune system homeostasis and reduce pathology. The potential for SNS targeted therapeutics comparable to the newly approved anti-TNF-α drugs is discussed.
Keywords: sympathetic nervous system, neural-immune, noradrenergic, rheumatoid arthritis
Letters in Drug Design & Discovery
Title: Catecholamines, Sympathetic Innervation and Immunity: Role in Experimental and Rheumatoid Arthritis
Volume: 1 Issue: 2
Author(s): D. Lorton and C. Lubahn
Affiliation:
Keywords: sympathetic nervous system, neural-immune, noradrenergic, rheumatoid arthritis
Abstract: The sympathetic nervous system (SNS) has a major role in homeostatic control of inflammatory and antigen specific immune reactions. This review summarizes the evidence that the SNS can enhance or suppress immune function, that SNS dysregulation is a critical component of the immune system dysregulation that underlies rheumatoid arthritis (RA) pathology and that the SNS may be targeted in RA to restore immune system homeostasis and reduce pathology. The potential for SNS targeted therapeutics comparable to the newly approved anti-TNF-α drugs is discussed.
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Cite this article as:
Lorton D. and Lubahn C., Catecholamines, Sympathetic Innervation and Immunity: Role in Experimental and Rheumatoid Arthritis, Letters in Drug Design & Discovery 2004; 1 (2) . https://dx.doi.org/10.2174/1570180043485518
DOI https://dx.doi.org/10.2174/1570180043485518 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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