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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis and Reactivity of α-Halogenated, C-Protected β-Enamino Acids

Author(s): S. Fustero, E. Salavert, J. F. Sanz-Cervera, R. Roman and B. Fernandez-Gutierrez

Volume 1, Issue 2, 2004

Page: [163 - 167] Pages: 5

DOI: 10.2174/1570178043488545

Price: $65

Abstract

C-Protected β-enamino acids (I) reacted with one equivalent of Nhalosuccinimides (NXS) to furnish their α-halogenated derivatives (II). These compounds were then successfully transformed into halogenated uracil derivatives (III) through reaction with triphosgene, followed by 5-membered ring-opening under acidic conditions.

Keywords: halogenation, enamino acid, uracil, oxazoline


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