Abstract
Biological membranes play an essential role in the drug action. They constitute the first barrier for drugs to exert their biological action. AT1 antagonists are amphiphilic molecules and are hypothesized to act on AT1 receptor through incorporation (first step) and lateral diffusion through membrane bilayers (second step). Various biophysical methods along with Molecular Modelling were applied in order to explore the plausible two step proposed mechanism of action for this class of antihypertensive drugs.
Keywords: Hypertension, AT1 receptor, antihypertensive drugs.
Current Topics in Medicinal Chemistry
Title: Efforts to Understand the Molecular Basis of Hypertension Through Drug:Membrane Interactions
Volume: 4 Issue: 4
Author(s): T. Mavromoustakos, P. Zoumpoulakis, I. Kyrikou, A. Zoga, E. Siapi, M. Zervou, I. Daliani, D. Dimitriou, A. Pitsas, C. Kamoutsis and P. Laggner
Affiliation:
Keywords: Hypertension, AT1 receptor, antihypertensive drugs.
Abstract: Biological membranes play an essential role in the drug action. They constitute the first barrier for drugs to exert their biological action. AT1 antagonists are amphiphilic molecules and are hypothesized to act on AT1 receptor through incorporation (first step) and lateral diffusion through membrane bilayers (second step). Various biophysical methods along with Molecular Modelling were applied in order to explore the plausible two step proposed mechanism of action for this class of antihypertensive drugs.
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Mavromoustakos T., Zoumpoulakis P., Kyrikou I., Zoga A., Siapi E., Zervou M., Daliani I., Dimitriou D., Pitsas A., Kamoutsis C. and P. Laggner , Efforts to Understand the Molecular Basis of Hypertension Through Drug:Membrane Interactions, Current Topics in Medicinal Chemistry 2004; 4 (4) . https://dx.doi.org/10.2174/1568026043451339
DOI https://dx.doi.org/10.2174/1568026043451339 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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