Abstract
Tau is a microtubule associated protein that is also the main component of the aberrant filaments that form aberrant structures like the neuropil threads or the neurofibrillary tangles, found in the brain of Alzheimers disease patients. The assembly of tau aberrant filaments could be reproduced in vitro by using a high concentration of tau protein or, at lower protein concentrations, by adding some compounds like polyanions, fatty acids (and derivates), and others. In this mini-review a descriptive analysis of the different conditions needed for in vitro tau polymerization are summarized.
Keywords: tau, assembly, polyanions, fatty acids and derivates
Current Alzheimer Research
Title: Assembly In Vitro of Tau Protein and its Implications in Alzheimers Disease
Volume: 1 Issue: 2
Author(s): Jesus Avila, Mar Perez, Jose J. Lucas, Alberto Gomez-Ramos, Ismael Santa Maria, Francisco Moreno, Mark Smith, George Perry and Felix Hernandez
Affiliation:
Keywords: tau, assembly, polyanions, fatty acids and derivates
Abstract: Tau is a microtubule associated protein that is also the main component of the aberrant filaments that form aberrant structures like the neuropil threads or the neurofibrillary tangles, found in the brain of Alzheimers disease patients. The assembly of tau aberrant filaments could be reproduced in vitro by using a high concentration of tau protein or, at lower protein concentrations, by adding some compounds like polyanions, fatty acids (and derivates), and others. In this mini-review a descriptive analysis of the different conditions needed for in vitro tau polymerization are summarized.
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Cite this article as:
Avila Jesus, Perez Mar, Lucas J. Jose, Gomez-Ramos Alberto, Maria Santa Ismael, Moreno Francisco, Smith Mark, Perry George and Hernandez Felix, Assembly In Vitro of Tau Protein and its Implications in Alzheimers Disease, Current Alzheimer Research 2004; 1 (2) . https://dx.doi.org/10.2174/1567205043332207
DOI https://dx.doi.org/10.2174/1567205043332207 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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