Quinone Methides as Alkylating and Cross-Linking Agents

Mauro      Freccero

Abstract

Quinone methides (QMs) are reactive intermediates involved in a large number of chemical and biological processes such as enzyme inhibition, DNA alkylation and cross-linking. Their electrophilicity towards amines, thiols, water, amino acids and peptides has been kinetically measured in aqueous solution. The alkylation process is often thermally and photochemically reversible and the resulting adducts may act as QM carriers.

Keywords: quinone methide electrophilicity, dna alkylation and enzyme inhibition

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Mini-Reviews in Organic Chemistry

Title: Quinone Methides as Alkylating and Cross-Linking Agents

Volume: 1 Issue: 4

Author(s): Mauro Freccero

Affiliation:

Keywords: quinone methide electrophilicity, dna alkylation and enzyme inhibition

Abstract: Quinone methides (QMs) are reactive intermediates involved in a large number of chemical and biological processes such as enzyme inhibition, DNA alkylation and cross-linking. Their electrophilicity towards amines, thiols, water, amino acids and peptides has been kinetically measured in aqueous solution. The alkylation process is often thermally and photochemically reversible and the resulting adducts may act as QM carriers.

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Cite this article as:

Freccero Mauro, Quinone Methides as Alkylating and Cross-Linking Agents, Mini-Reviews in Organic Chemistry 2004; 1 (4) . https://dx.doi.org/10.2174/1570193043403091

DOI https://dx.doi.org/10.2174/1570193043403091	Print ISSN 1570-193X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6298

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