Abstract
The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.
Keywords: cox-2 inhibitors, cox-2 selectivity, pre-clinical data
Mini-Reviews in Medicinal Chemistry
Title: First and Second Generations of COX-2 Selective Inhibitors
Volume: 4 Issue: 6
Author(s): Xavier de Leval, Fabien Julemont, Valerie Benoit, Michel Frederich, Bernard Pirotte and Jean-Michel Dogne
Affiliation:
Keywords: cox-2 inhibitors, cox-2 selectivity, pre-clinical data
Abstract: The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.
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Cite this article as:
Leval de Xavier, Julemont Fabien, Benoit Valerie, Frederich Michel, Pirotte Bernard and Dogne Jean-Michel, First and Second Generations of COX-2 Selective Inhibitors, Mini-Reviews in Medicinal Chemistry 2004; 4 (6) . https://dx.doi.org/10.2174/1389557043403693
DOI https://dx.doi.org/10.2174/1389557043403693 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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