Abstract
Direct enzymatic methods for the preparation of enantiopure cyclic β-amino acids (e.g. cispentacin) and β-lactams through the enzyme-catalyzed enantioselective ring opening of β-lactams in water and organic solvents are reviewed. Indirect methods through the lipase-catalyzed asymmetric acylation of N-hydroxymethylated β-lactams or the lipase-catalyzed hydrolysis of the corresponding ester derivatives, followed by ring opening, are also surveyed.
Keywords: lactam, amino acid, cispentacin, ring opening, enzymatic catalysis
Mini-Reviews in Organic Chemistry
Title: Direct and Indirect Enzymatic Methods for the Preparation of Enantiopure Cyclic β-Amino Acids and Derivatives from β-Lactams
Volume: 1 Issue: 1
Author(s): E. Forro and F. Fulop
Affiliation:
Keywords: lactam, amino acid, cispentacin, ring opening, enzymatic catalysis
Abstract: Direct enzymatic methods for the preparation of enantiopure cyclic β-amino acids (e.g. cispentacin) and β-lactams through the enzyme-catalyzed enantioselective ring opening of β-lactams in water and organic solvents are reviewed. Indirect methods through the lipase-catalyzed asymmetric acylation of N-hydroxymethylated β-lactams or the lipase-catalyzed hydrolysis of the corresponding ester derivatives, followed by ring opening, are also surveyed.
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Cite this article as:
Forro E. and Fulop F., Direct and Indirect Enzymatic Methods for the Preparation of Enantiopure Cyclic β-Amino Acids and Derivatives from β-Lactams, Mini-Reviews in Organic Chemistry 2004; 1 (1) . https://dx.doi.org/10.2174/1570193043488908
DOI https://dx.doi.org/10.2174/1570193043488908 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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