Abstract
Cyclosporin A (CsA) is a fungal metabolite that has immunomodulatory and anti-inflammatory effects. Cyclosporin binds to cyclophilin, inhibiting CD4-T-cell activation. In this paper we discuss the mechanism of action of CsA and its role as a novel approach for the treatment of allergic disease.
Keywords: allergic contact dermatitis, asthma, atopic dermatitis, cyclosporin, ocular allergic diseases, urticaria
Letters in Drug Design & Discovery
Title: Cyclosporin A: A Therapeutic Strategy in Allergic Diseases
Volume: 1 Issue: 4
Author(s): Nettis Eustachio, Colanardi Maria Cristina and Ferrannini Antonio
Affiliation:
Keywords: allergic contact dermatitis, asthma, atopic dermatitis, cyclosporin, ocular allergic diseases, urticaria
Abstract: Cyclosporin A (CsA) is a fungal metabolite that has immunomodulatory and anti-inflammatory effects. Cyclosporin binds to cyclophilin, inhibiting CD4-T-cell activation. In this paper we discuss the mechanism of action of CsA and its role as a novel approach for the treatment of allergic disease.
Export Options
About this article
Cite this article as:
Eustachio Nettis, Cristina Maria Colanardi and Antonio Ferrannini, Cyclosporin A: A Therapeutic Strategy in Allergic Diseases, Letters in Drug Design & Discovery 2004; 1 (4) . https://dx.doi.org/10.2174/1570180043398650
DOI https://dx.doi.org/10.2174/1570180043398650 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Coronary Artery Disease and Endothelial Dysfunction: Novel Diagnostic and Therapeutic Approaches
Current Medicinal Chemistry Yeast Network and Report of New Stochastic-Credibility Cell Cycle Models
Current Bioinformatics Acellular Spinal Cord Scaffold Implantation Promotes Vascular Remodeling with Sustained Delivery of VEGF in a Rat Spinal Cord Hemisection Model
Current Neurovascular Research Measurement of Physical Changes in the Myocardium for Development of Novel Methods for Diagnosing Ischemia
Current Cardiology Reviews Synthesis of 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3.3.3.0] Undecane-1- yl)-3-(4-hydroxyl-3-methoxyphenyl)-propionic Acid and its Inhibitory Effect on the Cervical Tumor U14 in vitro and in vivo
Medicinal Chemistry Ocular Toxocariasis: New Diagnostic and Therapeutic Perspectives
Recent Patents on Anti-Infective Drug Discovery Opportunities for Pharmacotherapy at the Intersection of Metabolic Syndrome and Hemostasis
Current Pharmaceutical Biotechnology The Role of Chest High Resolution CT and RT-PCR in Diagnosis of Different Stages of Coronavirus (COVID-19) Pneumonia
New Emirates Medical Journal Endothelial Function in Renal Transplant Recipients is Associated with Circulating Nitric Oxide, ACE Inhibitor Use and Time After Transplantation
Vascular Disease Prevention (Discontinued) Seasonal and Perennial Allergic Conjunctivitis
Recent Patents on Inflammation & Allergy Drug Discovery The Effect of Serotonin 5-HT2 Receptor Inhibitor on Vasomotor Responses
Vascular Disease Prevention (Discontinued) Hypoxia-Inducible Factor-1 in Arterial Disease: A Putative Therapeutic Target
Current Vascular Pharmacology Vasospastic Angina and Ca Channel Blockers
Current Hypertension Reviews Recent Advances in Developing Ophthalmic Formulations: A Patent Review
Recent Patents on Drug Delivery & Formulation Recent Advances in Sepsis Research: Novel Biomarkers and Therapeutic Targets
Current Medicinal Chemistry Preparation and Evaluation of Chitosan Submicroparticles Containing Pilocarpine for Glaucoma Therapy
Current Drug Delivery Computed Tomography Imaging of the Coronary Arteries: State of the Art Applications and Recent Patents
Recent Patents on Medical Imaging PET Radioligands for In Vivo Visualization of Neuroinflammation
Current Pharmaceutical Design The Effects of Obesity-Related Peptides on the Vasculature
Current Vascular Pharmacology ATP-Sensitive K+ Channels: Current and Putative Target for the Prevention and Treatment of Cardiovascular Diseases
Vascular Disease Prevention (Discontinued)