Abstract
A fusion protein (scu-PA:AV) was expressed in the baculovirus expression system and secreted from Sf9 cells lead by signal peptides, 2mel and 3egt. The scu-PA:AV displays both the urokinase activity and membrane binding activity of its parental components. Our work indicated that it is possible to be developed as a thrombus-targeting drug.
Keywords: protein expression, signal peptide, baculovirus-insect cell system, annexin v, low molecular weight urokinase
Protein & Peptide Letters
Title: Expression And Secretion Of Functional Recombinant 1 Scu-Pa:Av In Insect Cell Using Signal Peptides
Volume: 11 Issue: 1
Author(s): Yuhui Huang, Ruiyang Tian, Wei Hu, Xiangfu Wu, Shengli Yang and Yi Gong
Affiliation:
Keywords: protein expression, signal peptide, baculovirus-insect cell system, annexin v, low molecular weight urokinase
Abstract: A fusion protein (scu-PA:AV) was expressed in the baculovirus expression system and secreted from Sf9 cells lead by signal peptides, 2mel and 3egt. The scu-PA:AV displays both the urokinase activity and membrane binding activity of its parental components. Our work indicated that it is possible to be developed as a thrombus-targeting drug.
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Cite this article as:
Huang Yuhui, Tian Ruiyang, Hu Wei, Wu Xiangfu, Yang Shengli and Gong Yi, Expression And Secretion Of Functional Recombinant 1 Scu-Pa:Av In Insect Cell Using Signal Peptides, Protein & Peptide Letters 2004; 11 (1) . https://dx.doi.org/10.2174/0929866043478455
DOI https://dx.doi.org/10.2174/0929866043478455 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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