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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Expression And Secretion Of Functional Recombinant 1 Scu-Pa:Av In Insect Cell Using Signal Peptides

Author(s): Yuhui Huang, Ruiyang Tian, Wei Hu, Xiangfu Wu, Shengli Yang and Yi Gong

Volume 11, Issue 1, 2004

Page: [49 - 55] Pages: 7

DOI: 10.2174/0929866043478455

Price: $65

Abstract

A fusion protein (scu-PA:AV) was expressed in the baculovirus expression system and secreted from Sf9 cells lead by signal peptides, 2mel and 3egt. The scu-PA:AV displays both the urokinase activity and membrane binding activity of its parental components. Our work indicated that it is possible to be developed as a thrombus-targeting drug.

Keywords: protein expression, signal peptide, baculovirus-insect cell system, annexin v, low molecular weight urokinase


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