Abstract
The NK2 receptor (member of the tachykinin receptor family) is mainly located in the smooth muscle of the urinary, respiratory and gastrointestinal tracts, with limited presence in the CNS. This has raised interest in tachykinin NK2 receptor antagonists for the treatment of urological disorders, asthma. This review outlines progress done after 1998 in the field of NK2 small molecule antagonists, both acting on the NK1 / NK2, NK2 / NK3, NK1 / NK2 / NK3 receptors and selective for the NK2 one.
Keywords: nk2 receptor antagonists
Mini-Reviews in Medicinal Chemistry
Title: Small Molecule Antagonists of the Tachykinin NK2 Receptor [General Reviews]
Volume: 4 Issue: 3
Author(s): Daniela Fattori, Maria Altamura and Carlo Alberto Maggi
Affiliation:
Keywords: nk2 receptor antagonists
Abstract: The NK2 receptor (member of the tachykinin receptor family) is mainly located in the smooth muscle of the urinary, respiratory and gastrointestinal tracts, with limited presence in the CNS. This has raised interest in tachykinin NK2 receptor antagonists for the treatment of urological disorders, asthma. This review outlines progress done after 1998 in the field of NK2 small molecule antagonists, both acting on the NK1 / NK2, NK2 / NK3, NK1 / NK2 / NK3 receptors and selective for the NK2 one.
Export Options
About this article
Cite this article as:
Fattori Daniela, Altamura Maria and Maggi Alberto Carlo, Small Molecule Antagonists of the Tachykinin NK2 Receptor [General Reviews], Mini-Reviews in Medicinal Chemistry 2004; 4 (3) . https://dx.doi.org/10.2174/1389557043487376
DOI https://dx.doi.org/10.2174/1389557043487376 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Respiratory Stem Cells and Progenitors: Overview, Derivation, Differentiation, Carcinogenesis, Regeneration and Therapeutic Application
Current Stem Cell Research & Therapy Plant-based Anti-inflammatory Agents: Progress From Africa and China
Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) Current Concepts for Optimizing the Therapeutic Index of Glucocorticoid Receptor Ligands for Oral and Inhalative Use: Basic Considerations and Clinical Reality
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Adverse Reactions and Pathogen Safety of Intravenous Immunoglobulin
Current Drug Safety Current Options in the Treatment of Mast Cell Mediator-Related Symptoms in Mastocytosis
Inflammation & Allergy - Drug Targets (Discontinued) Biomarkers in the Management of Difficult Asthma
Current Topics in Medicinal Chemistry Role and Pharmacogenomics of TNF-α in Asthma
Mini-Reviews in Medicinal Chemistry Gene Therapy for Lung Diseases Development in the Vector Biology and Novel Concepts for Gene Therapy Applications
Current Molecular Medicine Enantioselective Desymmetrizations Promoted by Bifunctional Organocatalysts
Current Organocatalysis Microbes, Immunity and Multiple Sclerosis: An Update
Current Immunology Reviews (Discontinued) The University of New Mexico Center for Molecular Discovery
Combinatorial Chemistry & High Throughput Screening Body Mass Index (BMI) and Cognitive Functions in Later Life
Current Alzheimer Research Novel Approaches for Allergy
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents The Therapeutic Potential of Fungal Ribotoxins
Current Pharmaceutical Biotechnology Genetic Insights into Sepsis: What have we Learned and How will it Help?
Current Pharmaceutical Design Pharmacological Inhibition of Interleukin-8 (CXCL8) as a New Approach for the Prevention and Treatment of Several Human Diseases
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Arachidonic Acid Signaling in Pathogenesis of Allergy: Therapeutic Implications
Current Drug Targets - Inflammation & Allergy Vitamin E-Related Inhibition of Monocyte 5-Lipoxygenase and Cardiovascular Outcome in Maintenance Hemodialysis Patients
Recent Patents on Inflammation & Allergy Drug Discovery Regulatory T Cells as Targets for Immunotherapy of Autoimmunity and Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) Advances and Patents about Grinding Equipments with Nano-Particle Jet Minimum Quantity Lubrication
Recent Patents on Nanotechnology