Abstract
The introduction of combinatorial chemistry groups into pharmaceutical companies provoked a desire for efficient and effective methods for library design and optimisation. This, in turn, has resulted in a large number of scientific publications, detailing a variety of approaches to the problem. This review attempts to describe the major works in the literature, to set them in context both chronologically and scientifically, and to identify the outstanding challenges that must be addressed, if this area of research is to maintain the rapid progress seen hitherto.
Keywords: Optimisation, chronologically
Mini-Reviews in Medicinal Chemistry
Title: Methods for Library Design and Optimisation
Volume: 4 Issue: 10
Author(s): D. V.S. Green and S. D. Pickett
Affiliation:
Keywords: Optimisation, chronologically
Abstract: The introduction of combinatorial chemistry groups into pharmaceutical companies provoked a desire for efficient and effective methods for library design and optimisation. This, in turn, has resulted in a large number of scientific publications, detailing a variety of approaches to the problem. This review attempts to describe the major works in the literature, to set them in context both chronologically and scientifically, and to identify the outstanding challenges that must be addressed, if this area of research is to maintain the rapid progress seen hitherto.
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Cite this article as:
Green V.S. D. and Pickett D. S., Methods for Library Design and Optimisation, Mini-Reviews in Medicinal Chemistry 2004; 4 (10) . https://dx.doi.org/10.2174/1389557043403026
DOI https://dx.doi.org/10.2174/1389557043403026 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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