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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Antiviral Nucleoside Analogs Phosphorylation by Nucleoside Diphosphate Kinase

Author(s): S. Gallois-Montbrun, M. Veron and D. Deville-Bonne

Volume 4, Issue 4, 2004

Page: [361 - 369] Pages: 9

DOI: 10.2174/1389557043403990

Price: $65

Abstract

The reaction of NDP kinase was studied in vitro with several antiviral derivatives, using kinetic steady state and presteady state analysis. The enzyme is highly efficient with natural nucleotides but most of the analogs are slow substrates. The catalytic efficiency, also related to the affinity of the analog, is mainly dependent on the presence of a 3-OH group on the ribose moiety.

Keywords: ndp kinase, antiviral nucleoside analog, dideoxynucleoside, acyclovir, azt, d4t, 3tc, borano substitution


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