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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Role of Thymidine Kinases in the Activation of Pyrimidine Nucleoside Analogues

Author(s): Ashraf S. Al-Madhoun, Werner Tjarks and Staffan Eriksson

Volume 4, Issue 4, 2004

Page: [341 - 350] Pages: 10

DOI: 10.2174/1389557043403963

Price: $65

Abstract

Deoxynucleoside analogues need activation by deoxynucleoside kinases to serve as antiviral or anticancer agents. Here we review the properties of cellular cytoplasmic thymidine kinase 1, mitochondrial thymidine kinase 2, the multisubstrate deoxynucleoside kinase from Drosophila melanogaster and Herpes virus 1 thymidine kinase. Important substrate activity relationships will be discussed.

Keywords: tk1, tk2 dm-dnk, hsv1-tk, nucleoside analogues, chemotherapy, bnct

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