Advanced Pharmacophore Model of Non-Competitive AMPA Antagonist 2,3-benzodiazepines

Title: Advanced Pharmacophore Model of Non-Competitive AMPA Antagonist 2,3-benzodiazepines

Volume: 1 Issue: 3

Author(s): B. Rezessy and S. Solyom

Affiliation:

Keywords: non-competitive ampa antagonist,, 2,3-benzodiazepines, pharmacophore model, disco

Abstract: Detailed SAR examination and DIStance COmparison (DISCO) computation were used for identification and superposition of common structural features of 2,3-benzodiazepines with high affinity to an allosteric AMPA binding site. Two similar 4-point models were identified; both contained 2 donor sites, a donor atom and a hydrophobic centre. At one of the donor sites a characteristic difference between the two models was observed.

Cite this article as:

Rezessy B. and Solyom S., Advanced Pharmacophore Model of Non-Competitive AMPA Antagonist 2,3-benzodiazepines, Letters in Drug Design & Discovery 2004; 1 (3) . https://dx.doi.org/10.2174/1570180043398948