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Current Psychiatry Reviews

Editor-in-Chief

ISSN (Print): 1573-4005
ISSN (Online): 1875-6441

The Role of Cytokine Network in the Pathophysiology of Schizophrenia

Author(s): Yong-Ku Kim

Volume 1, Issue 2, 2005

Page: [123 - 131] Pages: 9

DOI: 10.2174/1573400054065604

Price: $65

Abstract

A growing body of evidence suggests that cytokines have a role in schizophrenia. Cytokines are involved in neurodevelopment, schizophrenic psychopathology, and neurodegeneration, and these processes are all part of the pathophysiology of schizophrenia. Cytokines modulate neuronal action, differentiation, and survival during neurodevelopment and are important factors in the processes of neurotoxicity and neurodegeneration. Cytokines also play a role in the activity and survival of neurons that utilize certain neurotransmitters, particularly dopamine, serotonin, and glutamate. This paper addresses the potential role of the cytokine network in the pathophysiology of schizophrenia.

Keywords: cytokine, antipsychotics, neurotransmitter, neurodegeneration, neurodevelopment, schizophrenia


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