[TIC4]Endomorphins, Analogues of Endomorphins, Have Significantly Enhanced Vasorelaxant Effects in Rat Aorta Rings

Title: [TIC4]Endomorphins, Analogues of Endomorphins, Have Significantly Enhanced Vasorelaxant Effects in Rat Aorta Rings

Volume: 12 Issue: 4

Author(s): Qian-Yu Zhao, Qiang Chen, Yun Feng, Xin Lin and Rui Wang

Affiliation:

Keywords: tic, endomorphins, opioid, vasorelaxant response, rat aorta rings

Abstract: [Tic4]EM1 and [Tic4]EM2, new endomorphins (EMs) analogues, caused relaxation of rat aorta rings precontracted with phenylphrine in a concentration-dependent manner and were 240- to 370-fold more potent than EMs. This effect was inhibited by endothelium removal or by incubation with NO synthase inhibitor L-NNA or opioid receptor antagonist naloxone. The results demonstrate that [Tic4]EMs have NO- and endothelium-dependent vasorelaxant effects which are mediated by the opioid receptor.

Cite this article as:

Zhao Qian-Yu, Chen Qiang, Feng Yun, Lin Xin and Wang Rui, [TIC4]Endomorphins, Analogues of Endomorphins, Have Significantly Enhanced Vasorelaxant Effects in Rat Aorta Rings, Protein & Peptide Letters 2005; 12 (4) . https://dx.doi.org/10.2174/0929866053765743