Abstract
This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.
Current Topics in Medicinal Chemistry
Title: New Approaches for the Treatment of Pain: The GDNF Family of Neurotrophic Growth Factors
Volume: 5 Issue: 6
Author(s): Dinah W. Y. Sah, Michael H. Ossipov, Anthony Rossomando, Laura Silvian and Frank Porreca
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Abstract: This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.
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Dinah W. Y. Sah , Michael H. Ossipov , Anthony Rossomando , Laura Silvian and Frank Porreca , New Approaches for the Treatment of Pain: The GDNF Family of Neurotrophic Growth Factors, Current Topics in Medicinal Chemistry 2005; 5 (6) . https://dx.doi.org/10.2174/1568026054367593
DOI https://dx.doi.org/10.2174/1568026054367593 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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