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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Involvement of PI3K/Akt Pathway in Prostate Cancer - Potential Strategies for Developing Targeted Therapies

Author(s): Nicole Pommery and Jean-Pierre Henichart

Volume 5, Issue 12, 2005

Page: [1125 - 1132] Pages: 8

DOI: 10.2174/138955705774933356

Price: $65

Abstract

This review presents some therapeutic interventions actually considered in prostate cancer therapy to compensate constitutive activation of the PI3K/Akt signalling pathway induced, particularly, by mutations of PTEN gene. Special emphasis is placed on applicability of EGF-R tyrosine kinase, COX-2, PDK-1, mTOR and farnesyltransferase inhibitors.

Keywords: Prostate cancer, PI3K/Akt/mTOR pathway, growth inhibition


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