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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Photosensitive Precursors to Nitric Oxide

Author(s): Christopher M. Pavlos, Hua Xu and John P. Toscano

Volume 5, Issue 7, 2005

Page: [637 - 647] Pages: 11

DOI: 10.2174/1568026054679326

Price: $65

Abstract

The photochemistry and use of recently developed photosensitive precursors to nitric oxide (NO) are reviewed. As "caged NO" donors these precursors are able to deliver NO in a spatially and temporally controllable manner. These properties have made such precursors useful in applications in biology and medicine, especially in elucidating neurophysiological roles of NO and in new cancer therapies.

Keywords: photodynamic therapy, diazeniumdiolate, nucleophiles, photolysis, meta substituents, photorelease


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