2,3,4,5- Tetrahydro- 1-Benzoxepines a Novel Class of Anti-Implantation Agents

Title: 2,3,4,5- Tetrahydro- 1-Benzoxepines a Novel Class of Anti-Implantation Agents

Volume: 2 Issue: 1

Author(s): Vishnu K. Tandon and Sanjay Rai

Affiliation:

Keywords: benzoxepines, anti-implantation, anti-fertility, non-steroidal, anti-estrogens

Abstract: 5- Substituted 2,3,4,5- Tetrahydro- 1-benzoxepine derivatives have been synthesized as novel antiimplantation agents. The synthesized compounds were evaluated for their anti-implantation activity in mature female Sprague-Dawley rats. The most active compounds in this series 10d and 11d, are 67% active in preventing implantation in rats at 10 mgkg-1 dose. We also found that the other compounds of the series have lesser anti-implantation activity compared to the most potent anti-implantation drug Centchroman 5.

Cite this article as:

Tandon K. Vishnu and Rai Sanjay, 2,3,4,5- Tetrahydro- 1-Benzoxepines a Novel Class of Anti-Implantation Agents, Letters in Drug Design & Discovery 2005; 2 (1) . https://dx.doi.org/10.2174/1570180053398253