A Simple, High Yield Route to cis-4-(N-Alkylamino)-L-Prolines

Title: A Simple, High Yield Route to cis-4-(N-Alkylamino)-L-Prolines

Volume: 2 Issue: 1

Author(s): Timothy P. Curran, Kevin A. Marques and Segufta I. Bilimoria

Affiliation:

Keywords: aminoproline, reductive amination, azide, aldehyde, secondary amine

Abstract: Reaction of 1 equivalent of N-“-acetyl-cis-4-azido-L-proline with 1 equivalent of an aldehyde and a catalytic amount of Pd-C under an H2 atmosphere cleanly and efficiently yields the corresponding N-“-acetylcis- 4-(N-γ-alkylamino)-L-proline derivative.

Cite this article as:

Curran P. Timothy, Marques A. Kevin and Bilimoria I. Segufta, A Simple, High Yield Route to cis-4-(N-Alkylamino)-L-Prolines, Letters in Organic Chemistry 2005; 2 (1) . https://dx.doi.org/10.2174/1570178053400063