Abstract
This article focuses on the synthesis of O6-substituted guanine derivatives and their application in medicine. O6-substituted guanines with alky-, aryl and heteroaryl-substituents and sterically challenging substituents have been described. The synthetic strategies are mainly based on different leaving groups in the 6-position of the guanine. Here, synthesis of various derivatives are described as well as the different synthetic pathways to obtain the synthetic precursors, which are prerequisites for efficient syntheses.
Keywords: substituted guanines, agt inhibitors, catalysis, rearrangement
Current Organic Synthesis
Title: Synthetic Strategies Towards O6-Substituted Guanine Derivatives and their Application in Medicine
Volume: 2 Issue: 2
Author(s): R. Schirrmacher, E. Schirrmacher, U. Mühlhausen, B. Kaina and B. Wängler
Affiliation:
Keywords: substituted guanines, agt inhibitors, catalysis, rearrangement
Abstract: This article focuses on the synthesis of O6-substituted guanine derivatives and their application in medicine. O6-substituted guanines with alky-, aryl and heteroaryl-substituents and sterically challenging substituents have been described. The synthetic strategies are mainly based on different leaving groups in the 6-position of the guanine. Here, synthesis of various derivatives are described as well as the different synthetic pathways to obtain the synthetic precursors, which are prerequisites for efficient syntheses.
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Cite this article as:
Schirrmacher R., Schirrmacher E., Mühlhausen U., Kaina B. and Wängler B., Synthetic Strategies Towards O6-Substituted Guanine Derivatives and their Application in Medicine, Current Organic Synthesis 2005; 2 (2) . https://dx.doi.org/10.2174/1570179053545369
DOI https://dx.doi.org/10.2174/1570179053545369 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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