Aromatic Polycationic Molecules with Restricted Conformations: An Alternative Approach to Antiherpes Agents

Title: Aromatic Polycationic Molecules with Restricted Conformations: An Alternative Approach to Antiherpes Agents

Volume: 2 Issue: 5

Author(s): Andrew Tsotinis, Margarita Vlachou, Andreas Eleutheriades, Peter J. Garratt, Ashley J. Ibbett, Yiu-Fai Ng, Christophe Pannecouque, Myriam Witvrouw and Erik De Clercq

Affiliation:

Keywords: polypodand aromatic cations, synthesis, antiherpes activity

Abstract: A series of aromatic polycationic molecules were synthesised and tested as potential non-classical antiherpes agents. Analogue (4) had a high potency in all four of the HSV cell lines used and is far more potent than ribavirin. The fact that none of the new compounds show any selectivity for HSV-2 over HSV-1 may imply that there is no intervention of a HSV-2 glycoprotein C (gC) dependent pathway.

Cite this article as:

Tsotinis Andrew, Vlachou Margarita, Eleutheriades Andreas, Garratt J. Peter, Ibbett J. Ashley, Ng Yiu-Fai, Pannecouque Christophe, Witvrouw Myriam and De Clercq Erik, Aromatic Polycationic Molecules with Restricted Conformations: An Alternative Approach to Antiherpes Agents, Letters in Drug Design & Discovery 2005; 2 (5) . https://dx.doi.org/10.2174/1570180054405758