Abstract
Cyclooxygenase and 5-lipoxygenase pathways, which convert arachidonic acid into prostaglandins and leukotrienes, respectively, are the two major pro-inflammatory routes, whereas lipoxins, resolvins and neuroprotectins are potent endogenous anti-inflammatory mediators. Modulation of these pathways is key to control inflammation and to promote its resolution.
Keywords: eicosanoids, prostaglandins, leukotrienes, lipoxins, resolvins, inflammation
Letters in Drug Design & Discovery
Title: New Perspectives in the Modulation of the Eicosanoid Cascade in Inflammation
Volume: 2 Issue: 5
Author(s): J. Claria and M. Lopez-Parra
Affiliation:
Keywords: eicosanoids, prostaglandins, leukotrienes, lipoxins, resolvins, inflammation
Abstract: Cyclooxygenase and 5-lipoxygenase pathways, which convert arachidonic acid into prostaglandins and leukotrienes, respectively, are the two major pro-inflammatory routes, whereas lipoxins, resolvins and neuroprotectins are potent endogenous anti-inflammatory mediators. Modulation of these pathways is key to control inflammation and to promote its resolution.
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Cite this article as:
Claria J. and Lopez-Parra M., New Perspectives in the Modulation of the Eicosanoid Cascade in Inflammation, Letters in Drug Design & Discovery 2005; 2 (5) . https://dx.doi.org/10.2174/1570180054405730
DOI https://dx.doi.org/10.2174/1570180054405730 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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