Abstract
The migration of leukocytes from the blood stream to sites of infection is a key event in cellular immune response, mediated by multiple types of molecules including several adhesion receptors. The inhibition of adhesion receptors holds great promise for novel therapeutical strategies to treat chronic inflammatory disorders or autoimmune diseases. This review reports on recent advances in adhesion-based therapeutics and focuses on structural classification of selectin and integrin inhibitors.
Keywords: adhesion molecules, autoimmune disease, endothelium, inflammation, integrins, leukocytes, selectins
Mini-Reviews in Medicinal Chemistry
Title: Inhibitors of Membrane Receptors Involved with Leukocyte Extravasation
Volume: 5 Issue: 6
Author(s): Gerd Bendas
Affiliation:
Keywords: adhesion molecules, autoimmune disease, endothelium, inflammation, integrins, leukocytes, selectins
Abstract: The migration of leukocytes from the blood stream to sites of infection is a key event in cellular immune response, mediated by multiple types of molecules including several adhesion receptors. The inhibition of adhesion receptors holds great promise for novel therapeutical strategies to treat chronic inflammatory disorders or autoimmune diseases. This review reports on recent advances in adhesion-based therapeutics and focuses on structural classification of selectin and integrin inhibitors.
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Bendas Gerd, Inhibitors of Membrane Receptors Involved with Leukocyte Extravasation, Mini-Reviews in Medicinal Chemistry 2005; 5 (6) . https://dx.doi.org/10.2174/1389557054023279
DOI https://dx.doi.org/10.2174/1389557054023279 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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