Allosterism at Muscarinic Receptors: Ligands and Mechanisms

N.   J.M.   Birdsall; S.      Lazareno

Abstract

The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

Keywords: muscarinic receptors, allosterism, cooperativity, enhancers, receptor models, structure-activity relationships, interaction studies, receptor subtype selectivity