Abstract
Hypoplastic Left Heart Syndrome (HLHS) is a devastating congenital cardiac defect affecting approximately one thousand newborns annually in the United States. Without surgery, this condition is universally fatal. Currently, there are three management options for children born with HLHS: the Norwood palliative surgical procedure, neonatal cardiac transplantation, and comfort care without surgery. In the following review, I will first briefly describe the anatomy and embryology of HLHS. I will then describe the three management options, including published survival statistics, neurodevelopmental outcomes, and other considerations for infants receiving each of the treatment options. I will also describe new developments that may improve outcomes in the near future. Published data of parental choices in the care of infants born with HLHS, as well as published data on physician attitudes towards the three treatment options will be presented. Finally, I will offer guidelines for physician-parent discussions drawing from the informed consent literature and case law.
Keywords: Hypoplastic Left Heart Syndrome, Decision Making, Treatment Outcome
Current Pediatric Reviews
Title: Current Outcomes and Considerations in Hypoplastic Left Heart Syndrome
Volume: 1 Issue: 3
Author(s): Alexander A. Kon
Affiliation:
Keywords: Hypoplastic Left Heart Syndrome, Decision Making, Treatment Outcome
Abstract: Hypoplastic Left Heart Syndrome (HLHS) is a devastating congenital cardiac defect affecting approximately one thousand newborns annually in the United States. Without surgery, this condition is universally fatal. Currently, there are three management options for children born with HLHS: the Norwood palliative surgical procedure, neonatal cardiac transplantation, and comfort care without surgery. In the following review, I will first briefly describe the anatomy and embryology of HLHS. I will then describe the three management options, including published survival statistics, neurodevelopmental outcomes, and other considerations for infants receiving each of the treatment options. I will also describe new developments that may improve outcomes in the near future. Published data of parental choices in the care of infants born with HLHS, as well as published data on physician attitudes towards the three treatment options will be presented. Finally, I will offer guidelines for physician-parent discussions drawing from the informed consent literature and case law.
Export Options
About this article
Cite this article as:
Kon A. Alexander, Current Outcomes and Considerations in Hypoplastic Left Heart Syndrome, Current Pediatric Reviews 2005; 1 (3) . https://dx.doi.org/10.2174/157339605774574926
DOI https://dx.doi.org/10.2174/157339605774574926 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Psychosocial Implications During Adolescence for Infant Heart Transplant Recipients
Current Cardiology Reviews Neurocognitive Monitoring and Care During Pediatric Cardiopulmonary Bypass — Current and Future Directions
Current Cardiology Reviews Aetiology, Diagnosis and Treatment of Hydrops Foetalis
Current Pediatric Reviews Pharmacological manipulation of peripheral vascular resistance in special clinical situations after pediatric cardiac surgery
Current Vascular Pharmacology Atrial Tachycardias Occurring Late After Open Heart Surgery
Current Cardiology Reviews Human Induced Pluripotent Stem Cells for Inherited Cardiovascular Diseases Modeling
Current Stem Cell Research & Therapy Pulmonary Vasodilators in the Management of Low Cardiac Output Syndrome After Pediatric Cardiac Surgery
Current Vascular Pharmacology Preoperative and Follow up Multi-Detector Row CT Angiography (MDCTA) in the Evaluation of Interrupted Aortic Arch (IAA)
Current Medical Imaging Structural Chromosome Abnormalities Associated with Obesity: Report of Four New Subjects and Review of Literature
Current Genomics Heart Transplantation for Congenital Heart Disease in the First Year of Life
Current Cardiology Reviews Cardiac Resynchronization Therapy in Children
Current Cardiology Reviews Sedation and Analgesia in Pediatric Intensive Care
Current Drug Targets Clinical Presentations and Diagnosis of Brucellosis
Recent Patents on Anti-Infective Drug Discovery A Systematic Review on Levosimendan in Paediatric Patients
Current Vascular Pharmacology Therapeutic Utilities of Pediatric Cardiac Catheterization
Current Cardiology Reviews Infants and Children with Tachycardia: Natural History and Drug Administration
Current Pharmaceutical Design Pituitary Stem Cells Drop Their Mask
Current Stem Cell Research & Therapy Economic Evaluation in Paediatric Practice: Examples from Cardiac Critical Care
Current Pediatric Reviews Pulmonary Complications After Congenital Heart Surgery
Current Respiratory Medicine Reviews Does Data Shape Moral Decision? Or Do Values Shape the Data?
Current Pediatric Reviews